Nanostructured Na2CaP2O7: A New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity

A facile and novel synthesis of thirteen 2-amino-3-cyanopyridine derivatives 5(a–m) by a one-pot multicomponent reactions (MCRs) is described for the first time, starting from aromatic aldehydes, malononitrile, methyl ketones, or cyclohexanone ammonium acetate in presence nanostructured diphosphate Na2CaP2O7 (DIPH) at 80 °C under solvent-free conditions. These compounds were brought into existence short period with good to outstanding yields (84–94%). The was synthesized characterized different techniques (FT-IR, XRD, SEM, TEM) used as an efficient, environmentally friendly, easy-to-handle, harmless, secure, reusable catalyst. Our study strengthened combining five new pyrido[2,3-d]pyrimidine 6(b, c, g, h, j) intermolecular cyclization 2-amino-3-cyanopyridines 5(b, formamide. products FT-IR, 1H NMR, 13C NMR comparing measured melting points known values reported literature. Gas chromatography/mass spectrometry characterize newly evaluate their purity. operating conditions optimized using model reaction which catalyst amount, temperature, solvent effect evaluated. Antibacterial activity tested against approved Gram-positive Gram-negative strains previously mentioned compounds.